We generate, from scratch, (custom) single domain antibodies. ‘Llamas and alpacas are endowed with heavy chain only antibodies from which single domain antibodies or VHHs are derived (Figure right). They are only 15 kDa in size (green, figure right), very stable, and an extremely versatile research tool to study & manipulate proteins in vitro, in cells or in organisms.

Because their cDNAs are available, Camelid nano-antibodies are amenable to tailored manipulation and modification. They have found their way to numerous applications. Broadly applicable, irrespective of the research domain in which they are used: cancer, inflammation, neurological disorders, amyloid disease, technology development in biochemistry, cell biology, structural biology, immunomodulation, …