Homing device on Lipid nanoparticle

Innovative Drug Delivery: Enhancing Lipid Nanoparticles with VHHs for Targeted Therapy

Lipid nanoparticles (LNPs) represent an exquisite and innovative means of transporting a cargo (drug) for controlled release during circulation in the body. A major concern for researchers and companies alike is to formulate the LNP accurately in terms of composition. We suggest that VHHs can be included on the surface of a LNP by prior covalent coupling to a specific lipid (see ‘ADC’ pictogram) and subsequent incorporation into an LNP. This approach would endow the particle with a specificity key, allowing the drug to reach its target site faster and and release its cargo locally where it is required to trigger a therapeutic effect.